Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.34
Which factors influence liver stiffness measured by realtime two dimensional shear wave elastography in patients on maintenance hemodialysis?
Danijela Zjačić Puljiz
; Department of Nephrology, Split University Hospital, Split, Croatia
Ivana Kristina Delić Jukić
; Department of Nephrology, Split University Hospital, Split, Croatia
Marko Puljiz
; Department of Emergency Medicine, Split Center for Emergency Medicine, Split, Croatia
Lučana Vicelić Čutura
; Department of Hematology, Split University Hospital, Split, Croatia
Iva Jerčić Martinić-Cezar
; Department of Transfusion Medicine, Split University Hospital, Split, Croatia
Dorotea Božić
; Department of Gastroenterology and Hepatology, Split University Hospital, Split, Croatia
Kristian Podrug
; Department of Gastroenterology and Hepatology, Split University Hospital, Split, Croatia
Željko Puljiz
; Department of Gastroenterology and Hepatology, Split University Hospital, Split, Croatia
Sažetak
Aim To evaluate liver stiffness (LS) by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to assess
its correlation with the mean arterial pressure (MAP) in patients on maintenance hemodialysis (MHD). The secondary
aim was to identify biological and biochemical parameters
associated with elevated LS.
Methods This study enrolled patients treated with MHD in
the Split University Hospital from December 2017 through
February 2018. LS was measured after a HD session using
RT 2D-SWE. Mean arterial pressure was measured before
RT-2D-SWE was performed.
Results The study enrolled 47 patients with the
mean±standard deviation age of 68.48±14.33 years. Arterial hypertension was diagnosed in 70.2% of patients. Liver
stiffness >7 kPa, suggesting clinically relevant fibrosis, was
found in 59.5% of patients. Arterial pressure was significantly correlated with LS (ρ=0.38, P=0.008). C-reactive protein (ρ=0.548, P=0.023), parathyroid hormone (ρ=0.507,
P=0.038), and total bilirubin (ρ=0.423, P=0.020) were correlated with elevated LS.
Conclusion Mean arterial pressure is correlated with increased LS in patients on MHD. Our results emphasize the
importance of proper regulation of arterial blood pressure
and indicate that LS should always be interpreted in combination with laboratory parameters. Further prospective
studies with larger series are needed.
Ključne riječi
Hrčak ID:
278026
URI
Datum izdavanja:
25.2.2021.
Posjeta: 358 *