Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.44
Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
Diana Ilić
orcid.org/0000-0002-1104-8144
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Nino Kunac
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Tina Borčić
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Petra Dinjar Kujundžić
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Zrinka Mišetić Dolić
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Nikola Sobočan
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Miloš Lalovac
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Maja Mijić
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Goran Međimurec
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Branislav Kocman
; Transplant Centre, Department of Surgery, Merkur University Hospital, Zagreb, Croatia
Ivana Mikolašević
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Tajana Filipec Kanižaj
; University of Zagreb, School of Medicine, Zagreb, Croatia
Sažetak
Neuroendocrine tumors (NET) are a rare and heterogeneous group of neoplasms with variable biological behavior.
They frequently metastasize to the liver, requiring active,
multimodality treatment. Surgical resection, possible in
only a minority of cases, was until recently the only potentially curative option. For unresectable NET with liver metastases, liver transplantation (LT) emerged as a potential
curative treatment due to relatively slow growth and indolent behavior of the metastases. In this case series with
literature review, we retrospectively analyzed the characteristics of 12 highly selected patients with metastatic NET
disease as an indication for LT treated in our center. We also
summarized the proposed prognostic factors, and evaluated and compared the existing selection criteria. The main
poor prognostic factors in our patients were high grade
NET and primary tumor in the pancreas. Inconsistent liver transplantation outcome parameters make it difficult
to standardize patient selection criteria. There is a need for
further studies that would fully elucidate the curative potential of LT in patients diagnosed with NET.
Ključne riječi
Hrčak ID:
278027
URI
Datum izdavanja:
25.2.2021.
Posjeta: 389 *