Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.59
Association of the imaging characteristics of desmoplasia on digital breast tomosynthesis and the Ki-67 proliferation index in invasive breast cancer
Kristina Samaržija
; Department of Radiology, Karlovac General Hospital, Karlovac, Croatia
Zoran Jurjević
; Department of Radiology, Karlovac General Hospital, Karlovac, Croatia
Sažetak
Aim To evaluate the imaging characteristics of desmoplasia on digital breast tomosynthesis (DBT) and their association with the Ki-67 index.
Methods Seventy-seven malignant spiculated breast
masses were analyzed in terms of tumor size, length and
width of spicules, coverage of tumor margin with spicules,
and the number of spicules. The Ki-67 index was obtained
from surgically removed tumor specimens.
Results The average spicule length was significantly negatively associated with a high Ki-67 (P=0.005, odds ratio
[OR] 0.252, 95% confidence interval [CI] 0.094–0.676), ie,
the lesions with longer spicules had a 3.968 times lower
odds of having a high Ki-67 than the lesions with shorter
spicules. The average spicule width at the base was significantly positively associated with Ki-67 (P=0.004, OR 3.939,
95% CI 1.520–10.209), ie, the lesions with thick spicules had
a 3.939 times higher odds of having a high Ki-67 than the
lesions with thin spicules. The lesions with more than 20
spicules and those with partially spiculated margins more
frequently had a high Ki-67 than those with fewer spicules
and fully spiculated margins, but the differences were not
significant.
Conclusion The spiculation analysis could be used as a
non-invasive method providing information about malignant lesions. The tumor proliferative activity, and therefore
the patient’s prognosis, might be predicted before biopsy
directly from DBT images
Ključne riječi
Hrčak ID:
278031
URI
Datum izdavanja:
25.2.2021.
Posjeta: 594 *