Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.360
Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
Laszlo Szalontai
; Medical Imaging Centre , Semmelweis University, Budapest, Hungary
Zsofia Jokkel
; Medical Imaging Centre , Semmelweis University, Budapest, Hungary
Tamas Horvath
; Department of Hydrodynamic Systems, Budapest University of Technology and Economics, Budapest, Hungary
Bianka Forgo
; Department of Radiology, Örebro University Hospital, Örebro, Sweden
Ildiko Kalina
; Medical Imaging Centre , Semmelweis University, Budapest, Hungary
Pal Maurovich Horvat
; Medical Imaging Centre , Semmelweis University, Budapest, Hungary
Philip L. Auyang
; Department of Cardiovascular Surgery Methodist De Bakey Heart & Vascular Center, Houston, Texas
M. Mujeeb Zubair
; Department of Cardiovascular Surgery Methodist De Bakey Heart & Vascular Center, Houston, Texas
Zsolt Garam
; Department of Cardiovascular Surgery Methodist De Bakey Heart & Vascular Center, Houston, Texas
David Laszlo Tarnoki
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Adam Domonkos Tarnoki
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Sažetak
Aim To investigate whether vertebrobasilar geometry contributes to the presence, severity, and laterality of white
matter hyperintensities (WMH).
Methods We retrospectively reviewed 290 cerebral scans
of patients who underwent time-of-flight and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) between 2017 and 2018. WMH were counted,
localized, and grouped according to laterality on the FLAIR
sequence. A 3D mesh of the posterior circulation was reconstructed (with ITK SNAP software) and the morphology
of the vertebrobasilar system analyzed with an in-house
software written in Python.
Results Patients were assigned into a group with WMH
(n=204) and a group without WMH (n=86). The severity
of WMH burden was mainly affected by age and hypertension, while the localization of the WMH (or laterality) was
mainly affected by the vertebrobasilar system morphology. Basilar artery morphology only affected the parietooccipital region significantly if both posterior communicating arteries were hypoplastic or absent. The dominant
vertebral artery and basilar artery curve had an opposite
directional relationship.
Conclusions An unequal vertebral artery flow is an important hemodynamic contributor to basilar bending. Increased basilar artery curvature and increased infratentorial WMH burden may signal inadequate blood flow and
predict cerebrovascular events.
Ključne riječi
Hrčak ID:
278444
URI
Datum izdavanja:
26.8.2021.
Posjeta: 316 *