Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2022.63.1 6
Incidence and risk factors for venous and arterial thromboses in hospitalized patients with coronavirus disease 2019: data on 4014 patients from a tertiary center registry
Ivana Jurin
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Marko Lucijanić
orcid.org/0000-0002-1372-2040
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Nevenka Piskač Živković
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Kristina Lalić
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Anamarija Zrilić Vrkljan
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Linda Malnar Janeš
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Ivona Kovačević
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Tomislav Čikara
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Anica Sabljić
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Nikolina Bušić
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Gorana Vukorepa
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Irzal Hadžibegović
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Ivica Lukšić
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Bruno Baršić
; Primary Respiratory and Intensive Care Center, University Hospital Dubrava, Zagreb, Croatia
Sažetak
Aim To evaluate the burden and predictors of throm
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boembolic complications in a large real-life cohort of hos
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pitalized patients with established coronavirus disease
2019 (COVID-19).
Methods We retrospectively reviewed the records of 4014
consecutive adult patients admitted to a tertiary-level insti
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tution because of COVID-19 from March 2020 to March 2021
for the presence of venous and arterial thrombotic events.
Results Venous-thromboembolic (VTE) events were pres
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ent in 5.3% and arterial thrombotic events in 5.8% patients.
The majority of arterial thromboses occurred before or on
the day of admission, while the majority of VTE events oc
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curred during hospitalization. The majority of both types
of events occurred before intensive care unit (ICU) admis
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sion, although both types of events were associated with
a higher need for ICU use and prolonged immobilization.
In multivariate logistic regression, VTE events were inde
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pendently associated with metastatic malignancy, known
thrombophilia, lower mean corpuscular hemoglobin con
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centration, higher D-dimer, lower lactate dehydrogenase,
longer duration of disease on admission, bilateral pneu
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monia, longer duration of hospitalization, and immobiliza
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tion for at least one day. Arterial thromboses were inde
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pendently associated with less severe COVID-19, higher
Charlson comorbidity index, coronary artery disease, pe
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ripheral artery disease, history of cerebrovascular insult, as
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pirin use, lower C reactive protein, better functional status
on admission, ICU use, immobilization for at least one day,
absence of hyperlipoproteinemia, and absence of meta
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static malignancy.
Conclusion Among hospitalized COVID-19 patients, ve
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nous and arterial thromboses differ in timing of presenta
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tion, association with COVID-19 severity, and other clinical
characteristics.
Ključne riječi
Hrčak ID:
278930
URI
Datum izdavanja:
17.2.2022.
Posjeta: 413 *