Izvorni znanstveni članak

https://doi.org/10.20471/acc.2022.61.01.08

Validacija kratke međunarodne kognitivne procjene multiple skleroze u velikoj kohorti bolesnika s relapsno-remitentnom multiplom sklerozom

Jelena Drulović orcid.org/0000-0002-4516-3458 ; Department of CNS Immune-Mediated Disorders, Department of Neurology, University Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Gordana Tončev ; Department of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Čongor Nadj ; Department of Neurology, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Dragana Obradović ; Department of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia
Jevto Eraković ; Department of Neurology, Clinical Center of Montenegro, Podgorica, Montenegro
Šarlota Mesaroš ; Department of CNS Immune-Mediated Disorders, Department of Neurology, University Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mirjana Čukić ; Department of Neurology, Clinical Center of Montenegro, Podgorica, Montenegro
Dejan Aleksić ; Department of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Marko Andabaka ; Institute of Genetics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Jovana Ivanović orcid.org/0000-0002-6803-9732 ; Department of CNS Immune-Mediated Disorders, Department of Neurology, University Clinical Center of Serbia, Belgrade, Serbia
Aleksa Jovanović orcid.org/0000-0002-1448-2843 ; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Marina Kostić ; Department of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia
Gorica Marić orcid.org/0000-0003-2739-142X ; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Aleksandar Marković ; Department of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia
Vanja Martinović ; Department of CNS Immune-Mediated Disorders, Department of Neurology, University Clinical Center of Serbia, Belgrade, Serbia
Aleksandra Parojčić ; Department of CNS Immune-Mediated Disorders, Department of Neurology, University Clinical Center of Serbia, Belgrade, Serbia
Stojan Perić orcid.org/0000-0002-2979-556X ; Department of CNS Immune-Mediated Disorders, Department of Neurology, University Clinical Center of Serbia, Belgrade, Serbia
Lorand Sakalaš orcid.org/0000-0002-5128-394X ; Department of Neurology, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Vesna Suknjaja orcid.org/0000-0003-1491-7912 ; Department of Neurology, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Katarina Vesić orcid.org/0000-0001-8861-4987 ; Department of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Sofija Vojvodić ; Department of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia
Tijana Vuković ; Department of Neurology, Clinical Center of Montenegro, Podgorica, Montenegro
Ralph H. B. Benedict ; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Tatjana Pekmezović orcid.org/0000-0001-7978-1409 ; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Sažetak

Kognitivno oštećenje je jedna od najčešće prijavljivanih manifestacija kod osoba s multiplom sklerozom (MS). Kratka
međunarodna kognitivna procjena multiple skleroze (engl. Brief International Cognitive Assessment for Multiple Sclerosis,
BICAMS) je baterija testova preporučena za brzu kognitivnu procjenu, koja je međunarodno standardizirana. Cilj našeg
istraživanja bio je procijeniti pouzdanost i validnost srpske verzije BICAMS-a. Ispitano je ukupno 500 bolesnika s relapsnoremitentnom
MS (RRMS) i 69 zdravih kontrolnih osoba (ZK) ujednačenih po uzrastu, spolu i razini obrazovanja. Svim
sudionicima u studiji napravljen je BICAMS, koji uključuje usmenu verziju Testa analogije simbola i brojeva (SDMT),
Kalifornijski test verbalnog učenja (CVLT-II), drugo izdanje i revidirani kratki test vizualne memorije (BVMTR). Nasumično
odabrana podskupina bolesnika je ponovno testirana 1-3 tjedna nakon prvog testiranja. Statistički značajne razlike između
bolesnika s MS i ZK zabilježene su za SDMT i BVMTR (p<0,001). ZK su imali viši zbroj CVLT-II, ali ova razlika
nije dostigla statističku značajnost (p=0,063). Kognitivno oštećenje definirano kao nenormalni rezultat testa na ≥1 subtestu
utvrđeno je kod 62,9% bolesnika s MS. Postojale su statistički značajne korelacije između rezultata testova BICAMS-a i
dobi, razine obrazovanja, proširene ljestvice onesposobljenosti (EDSS) i dužine bolesti u skupini bolesnika s MS. Pouzdanost
test-retest je potvrđena Pearsonovim koeficijentom korelacije od 0,70 u svim mjerenjima. Ova studija je pokazala pouzdanost
i validnost srpskog BICAMS-a, iako verzija CVLT-II koja je ovdje testirana nije bila osjetljiva za otkrivanje kognitivnih
poremećaja kod MS u usporedbi sa ZK.

Ključne riječi

Multipla skleroza; BICAMS; Kognicija; Kognitivno oštećenje; Validacija

Hrčak ID:

280118

URI

https://hrcak.srce.hr/280118

Datum izdavanja:

1.3.2022.

Podaci na drugim jezicima: engleski

Posjeta: 762 *