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Acta Dermatovenerologica Croatica, Vol. 28 No. 2, 2020.

Izvorni znanstveni članak

Assessment of the Quality of Life, Prevalence of Depression, and the Level of Interleukin 6 in Patients with Pemphigus Vulgaris

Dina Metwally ; Dermatology Department, Faculty of Medicine, Cairo University, Egypt
Marwa Fawzy ; Dermatology Department, Faculty of Medicine, Cairo University, Egypt
Mona El Kalioby ; Dermatology Department, Faculty of Medicine, Cairo University, Egypt
Rehab Hegazy ; Dermatology Department, Faculty of Medicine, Cairo University, Egypt
Rania Abdel Hay orcid id orcid.org/0000-0002-3280-0796 ; Dermatology Department, Faculty of Medicine, Cairo University, Egypt
Heba Abd-Elreheem ; Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Samir Abolmagd ; Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Nevine Elgarib ; Researcher at Cairo University, Cairo, Egypt

Puni tekst: engleski pdf 134 Kb

str. 57-62

preuzimanja: 246

citiraj

Sažetak

Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease affecting the skin and mucous membranes, exerting a detrimental
effect on the quality of life (QOL). Our aim was to evaluate the psychological
status and QOL of patients with PV and investigate Interleukin-6 (IL-6) as a possible contributor to the pathogenesis of pemphigus and associated depression.
The study included 22 patients with PV, 21 patients with depression, and 20
normal controls. All the 63 participants were subjected to assessment of their
QOL, psychiatric profile, as well as estimation of serum level of IL-6. All (100%) of
the included patients with PV had a negative effect on their QOL, which was significant compared with controls (P<0.001). Among patients with PV, 13 patients
(59.1%) had depression. IL-6 was non-significantly elevated in the pemphigus
group when compared with the controls (P=0.057). QOL was significantly worse
in the depressed pemphigus subgroup compared with the non-depressed pemphigus subgroup (P=0.006 and <0.001) respectively. However, IL-6 was non-significantly elevated in the depressed pemphigus subgroup compared with the
non-depressed pemphigus subgroup (P=0.095). A marked deterioration in the
QOL was observed in patients with pemphigus. More than 50%, but not all, of
patients with pemphigus had depression. IL-6 was non-significantly elevated in
patients with pemphigus.

Ključne riječi

pemphigus, quality of life, immunobullous disease

Hrčak ID:

281271

URI

https://hrcak.srce.hr/281271

Datum izdavanja:

16.7.2020.

Posjeta: 645 *