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Drug-induced Hypersensitivity Syndrome Caused by Lamotrigine, a Case Report

Danijela Vrhovski ; Emergency department, Clinical Hospital Sveti Duh, Zagreb, Croatia
Marina Ikić Matijašević ; Department of Clinical Immunology and Rheumatology, Clinical Hospital Sveti Duh, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Višnja Nesek Adam orcid id ; Emergency department, Clinical Hospital Sveti Duh, Zagreb, Croatia; University Department of Anesthesiology, Resuscitation and Intensive Care, Clinical Hospital Sveti Duh, Zagreb, Croatia; Faculty of Dental Medicine and Health, Osijek, Croatia

Puni tekst: engleski pdf 1.723 Kb

str. 88-92

preuzimanja: 329



Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also
known as drug-induced hypersensitivity syndrome (DIH S), is an under-recognized and potentially
life-threatening hypersensitivity reaction associated with a variety of medications, many of them antiepileptics.
Patients with DRESS syndrome typically present with rash, swelling, fever, and systemic
manifestations. We report a case of a patient admitted to out hospital after the administration of an
anticonvulsive drug lamotrigine. She was presented with high fever, rash, face oedema and elevated
liver enzymes. At admission, all previous medications were discontinued, systemic corticosteroid therapy
was administered, and the patient was monitored for signs of clinical recovery. This case report
suggests that in patients presenting with skin rash and systemic abnormalities after a recent change in
medications, physicians should consider DRESS syndrome as a possible diagnosis and switch to a
more aggressive therapy if removal of the offending agent does not result in clinical improvement.
Early diagnosis can reduce the risk of complications and the mortality rate.

Ključne riječi

Drug-induced hypersensitivity; drug reaction; lamotrigine

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Podaci na drugim jezicima: hrvatski

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