Pregledni rad
Insulin-like growth factors/receptors in lung cancer
Jasminka Pavelić
; Division of Molecular Medicine, Rudjer Bo{kovi} Institute, Zagreb, Croatia
Sažetak
Perturbation in a level of any peptide from insulin-like growth factor (IGF) family (ligands, receptors, binding proteins) seems to be implicated in lung cancer formation; IGF ligands and IGF-R1 through their mitogenic and antiapoptotic action, and the IGF-R2/M-6-P possibly as a tumor suppressor. In this respect we have found that human lung cancers overproduce IGF-1, IGF-2 and IGF-R1, which in turn stimulates their proliferation by autocrine mechanism, decrease apoptosis rate and increase telomerase activity. At the same time majority of tumors underproduce IGF-R2 possibly due to the mutations in both alleles of this gene. However, cancer cell proliferation can be abrogated or alleviated by blocking the mRNA activity of IGF-1, IGF-2 and/or IGF-R1 genes indicating that the use of monoclonal antibodies or an anti-sense approach may represent an effective and practical cancer gene therapy strategy.
Ključne riječi
insulin-like growth factors; receptors: lung cance
Hrčak ID:
281547
URI
Datum izdavanja:
30.11.2005.
Posjeta: 656 *