Izvorni znanstveni članak
https://doi.org/10.20471/acc.2021.60.s3.05
Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy
Jelena Šarić Jurić
orcid.org/0000-0002-2852-7993
; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, Croatia
Stjepan Jurić
orcid.org/0000-0001-8337-1656
; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, Croatia
Ivana Marković
orcid.org/0000-0002-0113-8373
; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, Croatia; Department of Neurology, Dubrava University Hospital, Zagreb, Croatia
Petra Jurić
orcid.org/0000-0002-7248-9891
; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ivana Jurić
orcid.org/0000-0002-2332-8055
; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Sažetak
Epilepsy is one of the most prevalent chronic neurological diseases, affecting about
70 million people worldwide. Patients with epilepsy often encounter cognitive dysfunction, which is
influenced by different factors including age at the onset of epilepsy, etiology of epilepsy, type of seizures,
seizure frequency and duration, psychiatric comorbidity, and antiepileptic drug (AED) therapy.
Event-related potentials are useful, noninvasive, objective clinical and research instrument for evaluation
of cognitive functions in patients. The aim of this study was to investigate and determine the effect
of AED monotherapy and polytherapy on cognitive changes in patients with epilepsy, detected
with P300 event-related potentials and compared with age- and gender-matched healthy individuals.
The study was conducted in 82 patients with generalized and focal epilepsy and 82 healthy individuals
aged 18-65 years. Cognitive evoked P300 potentials were recorded in all study subjects using auditory
‘oddball’ paradigm. The results showed the patients taking AED polytherapy to have a significantly
longer P300 latency and significantly lower N200-P300 amplitude. These results indicate that AED
polytherapy might worsen cognitive impairment in patients with epilepsy.
Ključne riječi
Antiepileptic drugs; Epilepsy; P300 event-related potentials; Cognitive impairment
Hrčak ID:
285128
URI
Datum izdavanja:
31.12.2021.
Posjeta: 587 *