Izvorni znanstveni članak

https://doi.org/10.11613/BM.2023.010701

Association of serum ADMA, SDMA and L-NMMA concentrations with disease progression in COVID-19 patients

Adnan Haşimi ; Department of Medical Biochemistry, Faculty of Medicine, Medipol University, Istanbul, Turkey
Özlem Doğan ; Department of Biochemistry, Ankara University School of Medicine, Ankara, Turkey
Ceyhan Ceran Serdar ; Medical Biology and Genetics, Faculty of Medicine, Ankara Medipol University, Ankara, Turkey
Muhittin A. Serdar ; Department of Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey

Sažetak

IntroductionThis study determines and compares the concentrations of arginine and methylated arginine products ((asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), n-monomethyl-1-arginine (L-NMMA) and homoarginine (HA)) for assessment of their association with disease severity in serum samples of COVID-19 patients.
Materials and methodsSerum arginine and methylated arginine products of 57 mild-moderate and 29 severe (N = 86) COVID-19 patients and 21 controls were determined by tandem mass spectrometry. Moreover, the concentrations of some of the routine clinical laboratory parameters -neutrophil lymphocyte ratio (NLR), C-reactive protein, ferritin, D-dimer, and fibrinogen measured during COVID-19 follow-up were also taken into consideration and compared with the concentrations of arginine and methylated arginine products.
ResultsSerum ADMA, SDMA and L-NMMA were found to be significantly higher in severe COVID-19 patients, than in both mild-moderate patients and the control group (P < 0.001 for each). In addition, multiple logistic regression analysis indicated L-NMMA (cut-off =120 nmol/L OR = 34, 95% confidence interval (CI) = 3.5-302.0, P= 0.002), CRP (cut-off = 32 mg/L, OR = 37, 95% CI = 4.8-287.0, P < 0.001), and NLR (cut-off = 7, OR = 22, 95% CI = 1.4-335.0, P = 0.020) as independent risk factors for identification of severe patients.
ConclusionsThe concentration of methylated arginine metabolites are significantly altered in COVID-19 disease. The results of this study indicate a significant correlation between the severity of COVID-19 disease and concentrations of CRP, NLR and L-NMMA.

Ključne riječi

SARS-CoV-2; asymmetric dimethylarginine (ADMA); N-monomethyl-1 -arginine (L-NMMA); prognosis

Hrčak ID:

287722

URI

https://hrcak.srce.hr/287722

Datum izdavanja:

15.2.2023.

Posjeta: 379 *