Psychiatria Danubina, Vol. 34 No. 4, 2022.
Izvorni znanstveni članak
https://doi.org/10.24869/psyd.2022.677
SERUM APELIN-13 LEVELS ARE DECREASED AMONG ADOLESCENTS DIAGNOSED WITH MAJOR DEPRESSIVE DISORDER
Sadettin Burak Acikel
orcid.org/0000-0002-8964-9513
; Ankara University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey
Abdulbaki Artik
orcid.org/0000-0001-7909-9944
; Uşak University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Kayseri, Turkey
Esra Hosoglu
; Giresun University, School of Medicine, Department of Child and Adolescent Psychiatry, Giresun, Turkey
Fatma Hümeyra Yerlikaya
; Prof. Selçuk University, School of Medicine, Department of Biochemistry, Konya, Turkey
Sažetak
Background: Apelin-13 have potential effect on mood because of high expression in the hypothalamus. In this study, we aimed to
investigate the serum apelin-13 levels among adolescents with major depressive disorder.
Subject and methods: A total of 42 patients between the ages of 12 and 18 with a primary diagnosis of major depressive disorder
have been included. Depression scores of both groups were measured by the Children’s Depression Inventory. Serum apelin-13
concentrations were measured by a commercially available kit based on enzyme-linked immunosorbent assay (ELISA) method.
Results: The mean serum apelin-13 levels in the patients with MDD was 173.08±106.33 pg/ml, whereas it was 251.75±167.82
pg/ml in healthy controls. The difference between groups in terms of mean serum apelin-13 levels was statistically significant
(p=0.018, Cohen’s d=-0.571).
Conclusion: This is the first study to examine the serum apelin-13 levels in adolescents diagnosed with major depressive
disorder. Lower serum apelin-13 levels were found in depressed adolescents.
Ključne riječi
depression; child/adolescent; mood disorders; biological markers
Hrčak ID:
291696
URI
Datum izdavanja:
22.12.2022.
Posjeta: 520 *