Psychiatria Danubina, Vol. 34 No. 4, 2022.
Izvorni znanstveni članak
https://doi.org/10.24869/psyd.2022.682
DECREASED NESFATIN-1 LEVEL IN OVERWEIGHT DEPRESSED PATIENTS
Gulsen Teksin
; Department of Psychiatry, University of Health Sciences Turkey, Sisli Hamidiye Etfal Teaching and Research Hospital, Istanbul Turkey
Musa Sahpolat
; Department of Psychiatry, Kilis State Hospital, Kilis, Turkey
Faruk Kurhan
; Department of Psychiatry, School of Medicine, Van Yuzuncu Yil University, Van, Turkey
Cem Sesliokuyucu
; Department of Psychiatry, Iskenderun State Hospital, Hatay, Turkey
Huseyin Bayazit
; Department of Psychiatry, Texas Tech University Health Science Center at Lubbock, Lubbock, Texas, United States of America
Sažetak
Background: Nesfatin-1 (NF-1) is a parameter that has been shown to have an important potential in the modulation of the
emotional state such as depression. The study focused to investigate the relationship between the plasma NF-1 level and depression.
Subjects and methods: Seventy-three patients who have a major depressive disorder (MDD) and 71 healthy individuals participated
in the study. Plasma NF-1 was analyzed by Enzyme Linked Immunosorbent Assay (ELISA) and compared according to the groups.
Results: The mean NF-1 was lower in the patients with MDD than being in the healthy (p:0.019). Plasma NF-1 level was
statistically significantly lower in the overweight MDD than in the non-overweight MDD (p:0.024). We observed a negative
correlation between plasma NF-1 level and age (r:-0.178, p:0.033), BMI (r:-0.212, p:0.011), HAM-D scores (r:-0.185, p:0.026).
However, there was no correlation for smoking status in both groups (r:0.095, p:0.259).
Conclusion: This study demonstrated the relationship between plasma NF-1 level and MDD as well as overweight. Therefore,
NF-1 might be related to certain nervous system pathologies as well as adipose tissue in the body.
Ključne riječi
depression; nesfatin-1; body mass index
Hrčak ID:
291697
URI
Datum izdavanja:
22.12.2022.
Posjeta: 229 *