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Genetic Diversity of 15 STR Loci in a Population of Montenegro
Nina Jeran
Dubravka Havaš
Vladislav Ivanović
Pavao Rudan
Sažetak
Genetic diversity and forensic parameters based on 15 AmpFlSTR Identifiler short tandem repeat (STR) loci (D8S1179,
D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818
and FGA) were evaluated in a sample of 101 unrelated, autochthonous adults from Montenegro. After applying Bonferroni
correction, the agreement with Hardy-Weinberg equilibrium (HWE) was confirmed for all loci with the exception
of D5S818 (c
2 test) and D21S11 (exact test). The combined power of discrimination (PD) and the combined power of exclusion
(PE) for the 15 studied loci were 0.9999999999999999844 and 0.99999382, respectively. According to measures
of within-population genetic diversity, D2S1338, D18S51 and FGA may be considered as the most variable and most informative
markers for forensic testing and population genetic analyses out of the 15 analysed loci in a population of
Montenegro. D5S818 showed to be the least variable and together with TPOX, the least informative. Interpopulation
comparisons were carried out and levels of genetic differentiation between population ofMontenegro and five South-eastern
European populations (Kosovo Albanians, Serbians from Vojvodina province, Macedonians, Bosnians and Croatians)
were evaluated. The most differentiated population in relation to Montenegro is a population of Kosovo Albanians
as suggested by both AMOVA and coefficients of genetic differentiation (FST and RST).
Ključne riječi
STRs; AmpFlSTR Identifiler; population genetics; genetic diversity; forensic genetics; Montenegro
Hrčak ID:
26899
URI
Datum izdavanja:
3.9.2007.
Posjeta: 1.668 *