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https://doi.org/10.5281/zenodo.6922018
Comparison and QSAR study of thermodynamic pKBH+ values of benzoylhydrazones determined by UV-Vis spectroscopy
Mirjana Jankulovska
orcid.org/0000-0002-3581-558X
; Ss. Cyril and Methodius University in Skopje, Faculty of Agricultural Sciences and Food - Skopje
Vesna Dimova
orcid.org/0000-0001-5062-7600
; Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje
Milena Jankulovska-Petkovska
; Faculty of Veterinary Medicine, University St. Kliment Ohridski
Abstract
Thermodynamic dissociation constants of fifteen protonated aromatic hydrazones were determined by UV-Vis spectroscopic method, as one of the main methods for determination of pKBH+ values of a weak acids and bases. The stoichiometric pKBH+ values of investigated compounds were determined at three different ionic strengths (0.1, 0.25 and 0.5 mol/dm3) in acidic media (1 < pH < 7). The thermodynamic pKBH+ values were evaluated graphically as an intercept with extrapolation to zero ionic strength of the curve which represents dependence of ionization constants on square root of ionic strength. The obtained results showed that there are no significant differences in the values of thermodynamic dissociation constants of investigated hydrazones with no substituent and metoxy group (–OCH3) on hydrazide part of the molecule. The differences in the pKBH+ values were noticed for hydrazones with nitro group (-NO2) on the benzene ring of benzaldehyde. Nitro hydrazones have lower pKBH+ values, probably due to the influence of the -NO2 group present in their molecule. The obtained pKBH+ values were in accordance with those for similar class of compounds. QSAR study has been made by correlation thermodynamic ionization constants with structure using various physicochemical parameters.
Keywords
Hrčak ID:
294683
URI
Publication date:
30.6.2022.
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