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Seroprevalence of Herpes Simplex Virus Type 2 in Adult HIV-Infected Patients and Blood Donors in Croatia

Oktavija Đaković Rode
Snježana Židovec Lepej
Josip Begovac

Puni tekst: engleski pdf 53 Kb

str. 693-695

preuzimanja: 374



The present study estimates herpes simplex virus type 2 (HSV-2) seroprevalence and evaluates its association with
age, sex, human herpesvirus type 8 (HHV-8) and human immunodeficiency virus (HIV) among adults in Croatia. A
cross-sectional survey included 166 HIV-infected patients and 219 blood donors. Antibodies against HSV-2 were determined
by enzyme immunoassays based on gG2 recombinant glycoprotein. HSV-2 seroprevalence was 45.8% in HIV-infected
patients and 8.7% in blood donors (p<0.0001; OR 8.8; 95% CI 5.05–15.49). Independent predictors of HSV-2
seropositivity were HIV infection (OR 11.0; 95% CI 5.93–20.41), female gender (OR 2.28; 95% CI 1.22–4.26), older age
(OR 3.93; 95% CI 2.74–7.11), and HHV-8 seropositivity (OR 2.72; 95% CI 1.09–6.75). Understanding the epidemiology of
HSV-2 is a critical first step in designing interventions to decrease HSV-2 and HIV transmission. The association of
HSV-2 with HIV infection and HHV-8 antibodies suggests a similar transmission route.

Ključne riječi

HSV-2, Croatia, HIV, blood donors, HHV-8, seroprevalence

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