Izvorni znanstveni članak
Effects of Nutritional Support in Patients with Colorectal Cancer during Chemotherapy
Renata Dobrila Dintinjana
Tina Guina
Željko Krznarić
Mladen Radić
Marijan Dintinjana
Sažetak
Nutritional support, addressing the specific needs of this patient group, is required to help improve prognosis, and reduce
the consequences of cancer-associated nutritional decline. Early intervention with nutritional supplementation has
been shown to halt malnutrition, and may improve outcome in some patients. In our study we tried to assess the influence
of nutritional support (counseling, oral liquids, megestrol acetate) on nutritional status and symptoms prevalence in patients
with colorectal cancer during chemotherapy. Group I consisted of 215 (55%) patients with medium age 68 2.6
years who were monitored prospectively and were given nutritional support. Group II included 173 (45%) patients (medium
age 67 2.9 years) without the proper nutritional counseling, in whom the data were collected retrospectively during
a 6 years period of time. After evaluation Nottingham Screening Tool Score, Appetite Loss Scale and Karnofsky Performance
Status) all patients in the group I received nutritional counseling, 153 of them (72%) were taking form of
enteral food supplement and 103 (48%) patients were using megestrol acetate. Evaluating the initial risk measurements
according to BMI, decrease in weight gain and NST, we did not find any significant difference between the two groups.
After chemotherapy completion, patients in group I had a 15.3% drop of those who’s BMI was <20,65% patients increased
their body weight, with an average weight gain of 1.5 kg (0.6–2.8 kg). Contrary, in group II we found increase in
weight loss ³2 kg/month in 39% of patients. The appetite improvement was detected on Appetite Loss Scale from 3.1
(pre-chemotherapy) to 4.7 (post-chemotherapy) in group I, especially in those receiving megestrol acetate. In both groups
Karnofsky Performance Status didn’t change significantly reflecting the impact of the disease itself and chemotherapy
procedures to the patient’s condition. Nutritional counseling, supplemental feeding and pharmacological support do
temporarily stop weight loss and improve appetite, social life and quality of life in those groups of patients. However, this
improvement have no implications on patients KPS and course of their disease.
Ključne riječi
nutritional support; colorectal cancer; chemotherapy
Hrčak ID:
27072
URI
Datum izdavanja:
2.9.2008.
Posjeta: 1.482 *