Acta clinica Croatica, Vol. 61. No. 3, 2022.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2022.61.03.12
Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma
Nenad Koruga
orcid.org/0000-0001-7555-1155
; Department of Neurosurgery, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, Croatia
Tatjana Pekmezović
orcid.org/0000-0001-7978-1409
; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Ilijan Tomaš
; Department of Oncology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, Croatia
Anamarija Soldo Koruga
; Department of Neurology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, Croatia
Ksenija Marjanović
; Department of Pathology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, Croatia
Jasmina Rajc
orcid.org/0000-0003-4007-8390
; Department of Pathology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, Croatia
Ante Rotim
; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Medicine, University of Zagreb, Zagreb, Croatia
Krešimir Rotim
; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Introduction: Glioblastoma represents the most aggressive tumor of the brain
with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of
neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two
decades, many studies were conducted with the aim of confirming viral influence in the development
of glioblastoma.
Methods: We conducted a retrospective study in a time period of five years using formalin-fixed
paraffin-embedded tissues of glioblastoma. Immunohistochemistry was performed for three viruses:
CMV, EBV and HSV-1, using an automated staining system.
Results: Mean age of patients in our group was 66.7±8.5 years. A slight male dominance was noted.
Negative immunohistochemistry results were obtained for CMV and EBV, which were excluded
from further investigation. Based on IRS score, we confirmed six HSV-1 samples which were rated as
IRS score 2. Five more samples of HSV-1 were rated as IRS score 1 and were excluded from the study.
Conclusion: According to our retrospective study and its results, we found no impact of neurotropic
viruses in the survival rate of glioblastoma. Further studies should be conducted including a wider
range of viral detection methods.
Ključne riječi
Glioblastoma; Brain Neoplasms; Cytomegalovirus; Herpes Simplex; Antibodies
Hrčak ID:
296142
URI
Datum izdavanja:
1.11.2022.
Posjeta: 621 *