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Antibiotic Use Optimization Program in the Largest Croatian University Hospital – Benefits of Restrictions on Unlimited Antibiotic Use
Robert Likić
Igor Francetić
Marinko Bilušić
Viktorija Erdeljić
Ksenija Makar-Aušperger
Carmen Junačko
Sažetak
The aim of this study was to obtain the relevant information on antibiotic use in a 750-bed Croatian university hospital.
The study has been designed as a 2-point prevalence interventional analysis. For each patient on antibiotic therapy,
diagnosis, indication for treatment, antibiotic therapy, dosage and route of administration together with the results of
microbiological studies (if available) were obtained. After the first prevalence analysis in 2001, a restriction on unlimited
antibiotic use was introduced. The second analysis, performed in 2002, after restrictions on antibiotic use, revealed reductions
in the rates of restricted release antibiotics and overall antibiotic use with decreases from 38.6% to 36.9% and
23.4% to 23.2% respectively (p=0.87). The first survey showed that the 5 most often prescribed antibiotics in the therapy
of bacterial infections were: gentamicin, other aminoglycosides, carbapenems, amoxycillin+clavulanate and vancomycin
with proportions of 14.8%, 10.3%, 8.2%, 7% and 7% respectively. In the year 2002, the most prescribed antimicrobial
drugs in the therapy of bacterial infections were: gentamicin, quinolones, vancomycin, carbapenems and cefuroxime with
proportions of 18.6%, 11.4%, 9.7%, 9.3% and 8% respectively. A reduction in the proportions of doubtful antibiotic therapy,
from 24.6% before the intervention, to 24.2% after the restrictions, accompanied by a 0.4% rise in the rates of indicated
antibiotic therapy was also observed (p=0.93). Our study shows that restrictions on formerly unlimited use of
antimicrobials, even when leading to an improvement in their prescribing, do not necessarily cause rapid and significant
reduction in the overall use of antibiotics or explicit positive financial effects.
Ključne riječi
antibiotic; antimicrobial therapy; antimicrobials; treatment; optimization; reduction; hospital
Hrčak ID:
27308
URI
Datum izdavanja:
4.1.2007.
Posjeta: 1.038 *