Izvorni znanstveni članak
Predictive Calculation of Effectiveness of a Regional Bone Marrow Donor Registry in Vojvodina, Serbia
Svetlana Vojvodić
Stevan L. Popović
Sažetak
The aim of this study was to determine the percentages of patients from Vojvodina who would find at least one HLA
identical unrelated donor in various sizes of donor files. To determine the probability that 200 patients will have given
phenotype, we defined three-locus haplotype frequencies through the phenotype frequencies of HLA A,B and DR antigens
as well as observed AB and BDR haplotype frequencies. Then we calculated the percentages of patients theoretically able
to have at least one HLA identical donor in a donor file of a certain size. According to the results of a study sample, predictive
estimation of the effectiveness of regional bone marrow donor registry in Vojvodina, would be 14% with 5,000 donors,
23% with 10,000 donors, 38.5% with 20,000 donors, 49.5% with 30,000 donors and 76% with 100,000 donors in the
registry. The appropriate size of registered donor file that would give at least one HLA identical donor for more than 45%
of patients from Vojvodina is 30,000 donors.
Ključne riječi
bone marrow; unrelated donors; effectiveness; percentage chart; Vojvodina; Serbia
Hrčak ID:
27409
URI
Datum izdavanja:
10.4.2007.
Posjeta: 793 *