Izvorni znanstveni članak

Apoptosis in Skin Cancer Development and Regression

Tanja Batinac
Gordana Zamolo
Alen Ružić
Viktor Peršić

Sažetak

Non-melanoma skin cancers (NMSC) are the most common malignant tumors in white population and their incidence
has been increasing worldwide. Molecular events regulating cell survival, apoptosis, growth arrest as well as cell
differentiation, are important contributors to the overall kinetics of benign and malignant cell growth and play a role in
their development, progression and regression. Failure of these pathways can result in the loss of control over proliferation
and lead to tumor development through the inactivation of tumor suppressor genes or the activation of oncogenes.
Also, immunological mechanisms have been implicated in a phenomenon of tumor progression as well as spontaneous
tumor regression. We have tried to summarize the main events in etiopatogenesis, development, progression and in some
cases skin cancer regression. Further studies are needed to elucidate completely the details of apoptotic control in normal
skin and determine factors resulting in apoptotic disbalance and disease.

Ključne riječi

apoptosis; basal cell carcinoma; keratoacanthoma; squamous cell carcinoma

Hrčak ID:

27416

URI

https://hrcak.srce.hr/27416

Datum izdavanja:

16.1.2007.

Posjeta: 1.398 *