Original scientific paper
Nutrition, Body Weight and Deterioration of Familial Combined Hyperlipidemia
Judita Koprovičová
Jozef Kollár
Darina Petrášová
Abstract
Lipid and apolipoprotein serum levels as a consequence of excessive nutrition in the overweight individuals with familial
combined hyperlipidemia (FCHL) in comparison with the obese ones are studied only sporadically. In this study,
the effect of overweight and obesity in subjects with FCHL on serum lipids and apolipoproteins was investigated. The
participants were 36 overweight and 10 obese men. 17 normolipidemic healthy men served as the control group. The
mean age of all subjects included was 49±9 years. Lipid and apolipoprotein serum levels were determined by standard
methods. The increased body weight in overweight men with FCHL correlates with increased cholesterol and triacylglycerol
serum levels (p<0.001), atherogenous ratio values, apolipoprotein serum levels – apo C-III, apo C-II and apo
B100 (p<0.001) as well as decreased HDL cholesterol serum levels (p<0.05). Lipid metabolism in men with FCHL is deteriorated
by a high energy intake and its low output. The overweight and not only obesity, in association with FCHL, is an
important risk factor for premature development of ischemic events.
Keywords
overweight; obesity; hypercholesterolemia; hypertriacylglycerolemia; apolipoproteins; lipids
Hrčak ID:
27666
URI
Publication date:
13.12.2006.
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