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Persistant Immunodominant Anti-Gag SLYNTVATL Responses in HIV-Patients with up to 7 Years of HAART

Snježana Židovec Lepej
Ela Kosor
Alenka Gagro
Adriana Vince
Anica Remenar
Mario Poljak

Puni tekst: engleski pdf 159 Kb

str. 33-38

preuzimanja: 414



We analyzed Gag-specific CD8+ T-cells in HIV-patients on long-term HAART and in untreated chronically-infected
patients by using iTAg MHC class I tetramers (HLA-A*0201) specific for SLYNTVATL. Gag SLYNTVATL-specific CD8+
T-cells were detectable in 18 of 26 treated patients (median 5.2 years of HAART) and in 10 of 14 untreated patients. Median
percentage of Gag SLYNTVATL-specific CD8+ T-cells in treated patients was 0.10 (range 0.00–0.70%). Median number
of Gag SLYNTVATL-specific CD8+ T-cells per 50,000 CD8+ T-cells was 56.0 cells (range 2.0–344.0 cells) and was not significantly
different compared with untreated patients (p=0.978). Numbers of Gag SLYNTVATL-specific CD8+ T-cells were inversely
correlated with the duration of undetectable plasma viremia (p=0.02, Rho= –0.430). Chronically-infected HIVpatients
on HAART (for up to 7.7 years) maintained a stable subpopulation of Gag SLYNTVATL-specific CD8+ T-cells. This
finding is relevant for the analysis of treatment-induced immune reconstitution and, possibly, for future therapeutic
strategies in HIV-disease.

Ključne riječi

HIV-1, MHC class I tetramer, HAART, CD8, immune reconstitution

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