Meeting abstract
https://doi.org/10.26800/LV-145-supl2-BS07
Molecular effects of stable gastric pentadecapeptide BPC 157 on psoriasis
Hrvoje Vraneš
; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia
Luka Kalogjera
Ivan Maria Smoday
Abstract
Psoriasis is a chronic, relapsing, immune-mediated skin disease. Etiopathogeniesis of psoriasis includes pro-inflammatory cytokines such as:
TNF-alpha, IL-12, IL-17, IL-23 etc. IL-17 exerts its effect by binding to IL-17R (Interleukin-17 receptor) on keratinocytes. Keratinocytes then in response produce β2-defensin. β-defensins have multiple antimicrobial and pro-inflammatory effects that are observed in psoriasis. Since stable gastric pentadecapeptide BPC 157 has shown anti-inflammatory effects in several studies, in this research we explored antiinflammatory effects of BPC 157 on molecular level in psoriasis.
Keywords
BPC 157; pharmacology; psoriasis
Hrčak ID:
303007
URI
Publication date:
23.4.2023.
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