Izvorni znanstveni članak

https://doi.org/10.24099/vet.arhiv.1862

Biological characterization of isolated pigeon Paramyxovirus-1 and its pathogenicity analysis in SPF chickens

Yuxia Zhang ; Poultry Institute, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Poultry Diseases Diagnosis and Immunology, Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, China
Sufang Ren ; Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China
Xiaoyuan Yuan ; Poultry Institute, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Poultry Diseases Diagnosis and Immunology, Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, China
Jinxing Yang ; Poultry Institute, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Poultry Diseases Diagnosis and Immunology, Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, China
Wu Ai ; Poultry Institute, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Poultry Diseases Diagnosis and Immunology, Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, China
Kai Meng ; Poultry Institute, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Poultry Diseases Diagnosis and Immunology, Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, China

Sažetak

Pigeon paramyxovirus type 1 (PPMV-1) is considered as an antigenic variant of Newcastle Disease leading to high mortality and significant economic losses to the poultry industry. However, the pathogenicity of PPMV-1 to chickens is still unclear. Herein, we reported the biological characterization of the isolated PPMV-1 from the diseased pigeons suspected to Newcastle Disease and studied its pathogenicity in SPF chickens. The phylogenetic tree and evolution distances revealed that the new isolate belonged to a VI.2.1.1.2.2 sub-genotype of NDV. Despite the cleavage motif of the F protein containing the 112RRQKR↓F117 sequence associated with virulent NDV strains, and the value of MDT and ICPI of the isolate showing mesogenic characteristics, the challenge trial showed that the isolate had weak pathogenicity to chickens while causing lesions in multiple tissues and organs in pigeons.

Ključne riječi

PPMV-1; VI.2.1.1.2.2 sub-genotype; genetic characterization; pathogenicity

Hrčak ID:

303106

URI

https://hrcak.srce.hr/303106

Datum izdavanja:

24.5.2023.

Podaci na drugim jezicima: hrvatski

Posjeta: 626 *