Izvorni znanstveni članak
https://doi.org/10.20471/dec.2023.59.02.05
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression
Oscar Fernando Moreno Adaro
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Claudio Berríos Bravo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Manuel Alejandro Guevara
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Gonzalo Mesones
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Leticia Sabina
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Daniela Mulet
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Ainura Okasova
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Ricardo Andrada
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Ángel José Martín Gargiulo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Mercedes María Lucrecia Gargiulo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Augusto Pascual Ítalo Gargiulo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Marcos Constantino Josué Gargiulo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Norman López Velásquez
; Universidad de la Costa, Atlántico, Colombia
José Vicente Lafuente
; Laboratorio de Neurociencias Clínicas y Experimentales, Universidad del País Vasco (UPV/EHU), Leioa, Spain
Adriana Inés Landa De Gargiulo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina
Humberto Luis Mesones Arroyo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina; Argentine Association of Psychiatrists, Buenos Aires, Argentina
Pascual Ángel Gargiulo
; Laboratory of Neurosciences and Experimental Psychology, Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina; Argentine Association of Psychiatrists, Buenos Aires, Argentina; Cathedra of Psychopathology, Faculty of Humanities and Economical Sciences, Catholic University of Argentina, Buenos Aires, Argentina
Sažetak
A relevant role has been attributed to phenethylamine in depressive disorders. It has been measured in human urine and rat brain in pathological conditions and after drug administration. Furthermore, a clinical correlation has been proposed between urinary elimination and depressive symptoms. Furthermore, its metabolic predecessor, D-phenylalanine, has been used as an antidepressant drug in the treatment of depressive disorders. The use of this amino acid has been realized alone, or in combination with classical antidepressants. In the present study, we tried to characterize its behavioural profile comparing it with imipramine and fluoxetine. Antidepressant drugs have been studied using diverse animal models. We used here the Porsolt test, or Forced Swimming Test (FST), measuring times of climbing, swimming and resting. When a comparison was performed between groups in climbing behaviour, significant differences were observed between imipramine treated group and saline controls (p < 0.05), and imipramine versus fluoxetine and D-phenylalanine (p < 0.01). When swimming was evaluated, clear differences between D-phenylalanine and the other groups were observed (p < 0.001). Additionally, a significant difference was also observed between imipramine and fluoxetine (p < 0.01). When resting was evaluated, high differences between D-phenylalanine versus all other groups were shown (p < 0.001). Observed behavioural profile was according to serotonergic antidepressant drugs effects. It is supported by the fact that swimming behaviours were increased, and a correlative decrease in resting was also present. We conclude that D-phenylalanine showed higher antidepressant potency than other classical antidepressants, at least at the doses used.
Ključne riječi
Phenylalanine; imipramine; fluoxetine; antidepressive agents; behaviour
Hrčak ID:
304152
URI
Datum izdavanja:
19.6.2023.
Posjeta: 459 *