Review article
https://doi.org/10.31306/s.65.2.5
The role of matrix metalloproteinases in the development of environmental diseases
Ivana Šutić
orcid.org/0000-0002-3157-538X
; Medicinski fakultet Rijeka, Rijeka, Hrvatska
Marija Bubaš
; Hrvatski zavod za javno zdravstvo, Zagreb, Hrvatska
Aleksandar Bulog
orcid.org/0000-0001-6283-9248
; Medicinski fakultet Rijeka, Rijeka, Hrvatska
Abstract
The incidence of environmental diseases, especially in highly developed industrial countries, has increased by more than 30% in the last few decades. These diseases represent a burden for both the individual and public health. Many of them (asthma, allergic rhinitis, chronic obstructive pulmonary disease, cardiovascular diseases) are a major public health problem, and it is necessary to identify harmful environmental factors, determine the mechanisms of their action, find adequate markers for early diagnosis and disease monitoring. By doing that better preventive and therapeutic effects can be achieved. In order to prevent the development of environmental diseases and to preserve environmental health in addition to knowing mechanisms by which harmful compounds enter the ecosystem (e.g. unintentional discharge, waste disposal, operation of industrial plants, transport) toxic kinetics is also important, i.e. absorption, biological conversion, distribution and excretion of harmful compounds and their metabolites from the organism. Intracellular matrix metalloproteinases (MMPs) are localized in various compartments within the cell including the cytosol, sarcomere, mitochondria, and nucleus. Intracellular MMPs contribute to the pathogenesis of various diseases. These include diseases with altered immune responses, cardiovascular diseases, respiratory diseases, inflammation, renal disorders, and malignant diseases. MMPs have antiviral and bactericidal effects and can act intracellularly through protease-dependent mechanisms. In addition to their immune status they are proven to be a good marker for monitoring environmental diseases. In addition to diagnosing and monitoring environmental diseases, MMPs and their tissue inhibitors (TIMPs) represent a potential treatment goal.
Keywords
Hrčak ID:
305264
URI
Publication date:
3.7.2023.
Visits: 353 *