Izvorni znanstveni članak
Cholinesterase Unit Establishment and Issuing of »Warning Cards« for Carriers of Suxamethonium Sensitive Serum Butyrylcholinesterase Variants
Branka Šurina
Dražen Nosso
Zoran Šiftar
Zlata Flegar-Meštrić
Vera Simeon-Rudolf
Sažetak
Recognition of butyrylcholinesterase (EC 3.1.1.8) variants in human serum is essential
to identify patients who may be susceptible to a prolonged reaction of suxamethonium
and mivacurium, short-acting muscle relaxants. Thus they can be given appropriate
advice along with their relatives who may be similarly affected. Therefore, Cholinesterase
Unit for detection of individuals, carriers of inherited suxamethonium sensitive
butyrylcholinesterase variants was established at the Institute for Clinical Chemistry of
the Clinical Hospital »Merkur«, Zagreb, Croatia. A study was conducted on sera from
patients referred to the Unit. Butyrylcholinesterase variants were determined by measuring
the enzyme activity and inhibition by specific inhibitors in the sera of 384 patients
and of the members of seven families. Cholinesterase Unit issued »Warning Cards«
to the carriers of inherited serum butyrylcholinesterase variants in order to avoid prolonged
apnea that suxamethonium might cause.
Ključne riječi
butyrylcholinesterase; serum cholinesterase; cholinesterase variants; suxamethonium; neuromuscular relaxants; warning cards
Hrčak ID:
28054
URI
Datum izdavanja:
28.12.2004.
Posjeta: 1.115 *