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Synthetic Modifications of Ascomycin. V. Access to Novel Ascomycin Derivatives by Replacement of the Cyclohexylvinylidene Subunit

Reinhold Zimmer
Karl Baumann
Hildegard Sperner
Gerhard Schulz
Ewald Haidl
Maximilian A. Grassberger


Puni tekst: engleski pdf 161 Kb

str. 17-27

preuzimanja: 519

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Sažetak

Starting from the easily accessible 24-O-tert-butyldimethylsilyl-22(R)-dihydro-28-oxoascomycin, methodologies that allow replacement of the cyclohexylvinylidene moiety of ascomycin by various other substituents are described. In addition, a so far unknown reactivity of the masked tricarbonyl moiety of ascomycin towards a stabilized Wittig reagent is reported.

Ključne riječi

ascomycin, immunosuppressiva, aldol reaction, oxime, Wittig reaction, oxidation

Hrčak ID:

2661

URI

https://hrcak.srce.hr/2661

Podaci na drugim jezicima: hrvatski

Posjeta: 971 *