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Unilateral Multicentric Breast Cancer

Josip Fajdić
Damir Buković
Damir Gugić
Mario Habek
Iva Hojsak
Nevija Buković
Ivan Herman
Tajana Stančerić

Puni tekst: engleski pdf 108 Kb

str. 693-698

preuzimanja: 1.032



Clinical characteristics of unilateral multicentric breast cancer (UMBC) were explored
depending on aggressiveness, survival rate, disease-free period and local recurrence.
The study included 296 women with breast cancer, surgically treated between 1990 and
2001. UMBC was histologically proved in 29 (9.8%) patients. Multicentricity was defined
by following criteria: a) tumor with minimum one satellite node in the same or
other quadrant of the breast; b) minimum one cut through the breast without tumor
cells; c) histopathologically, discontinued tumors with intra-ductal invasion. The average
age of patients was 63.4 (range 36–85). There were 9 (31.0%) women with one satellite
node, 7 (24.1%) women with two satellite nodes, and 13 (44.8%) women with three or
more satellite nodes. At the operation, axilla was positive in 20 (68.9%) women. Steroid
receptors were highly positive in 12 (41.4%) patients. Primary and secondary tumors
were of the same histological type in 26 (89.6%) patients. Local recurrence was found in
only 3 (10.3%) patients. A five-year period without disease was achieved in 24 (82.7%)
women. Kaplan-Meier analysis showed a significantly higher survival rate at lower tumor
stages (I or II) unlike in advanced stages with predominantly N2 grade. The results
of this study showed a slightly lower five-year disease-free period than in the case of patients
with monocentric breast cancer (MOBC). The survival rate was significantly lower
at all advanced stages, especially determined by N2 axilla. Therefore, the conclusion
is that multicentricity doesn’t increase the risk of poor prognosis, especially at lower
tumor stages.

Ključne riječi

breast cancer, UMBC, MOBC

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