Izvorni znanstveni članak
Circadian Rhythm of Blood Leptin Level in Obese and Non-Obese People
Radivoje Radić
Vasilije Nikolić
Ivan Karner
Pašezada Kosović
Sven Kurbel
Robert Selthofer
Mario Ćurković
Sažetak
Leptin, an adipose tissue hormone, has circadian variations in its secretion. Aims of
this study were to show how circadian rhythm depends on fat tissue distribution in
obese and non-obese subjects. The research was carried out on 70 subjects (37 men and
33 women) with an average body mass index (BMI) of 25.22 kg/m2. Concentration of
leptin in blood was measured at 8.30 a.m., 12.30 p.m. and 6.30 p.m. Basal leptin level
correlated strongly with all isolated regions of subcutaneous fat tissue in women and
obese subjects. Circadian changes of blood leptin level in non-obese people are more significant
than these changes in obese people. Differences in circadian pattern of leptin secretion
between obese and non-obese subjects were probably caused by enlarged volume
of subcutaneous fat tissue in obese people. Lean subjects have subcutaneous fat in physiological
range which allows influence of some hormones (insulin or cortizol) or food intake
on leptin secretion.
Ključne riječi
leptin; circadian rhythm; obese; non-obese
Hrčak ID:
28188
URI
Datum izdavanja:
15.12.2003.
Posjeta: 2.097 *