Izvorni znanstveni članak
Bayesian Approach to Searching for Susceptibility Genes: Gc2 and EsD1 Alleles and Multiple Sclerosis
M. Di Bacco
D. Luiselli
M. L. Manca
G. Siciliano
Sažetak
Multiple sclerosis (MS) is one of the most common causes of neurological disability
in early adulthood. The current literature is interested in identifying biological or DNA
markers associated with genetic susceptibility to MS. The aim of this study is to investigate,
by means of Bayesian statistical inference, whether the presence of Gc2 (Gc =
group-specific component) and/or EsD1 (EsD = esterase D) alleles affects MS susceptibility.
Gc and EsD are two classical genetic markers, being the first a serum protein
polymorphism, the latter an isoenzyme polymorphism. The interest of the proposed statistical
approach of searching for MS susceptibility genes relies on the analysis of two
different functions, one function being inferred from our results on 56 unrelated patients
from central Italy affected by MS, the other one from Italian and worldwide epidemiological
data. The graphical analysis suggests that MS susceptibility is influenced
by both Gc2 and EsD1 alleles; and EsD1 allele is more informative than Gc2. These results
point out the advantages of the Bayesian approach in searching for susceptibility
genes. Furthermore, the significant association between the considered alleles and the
susceptibility to MS suggests possible hypotheses about the pathogenesis of the disease.
Ključne riječi
Hrčak ID:
28247
URI
Datum izdavanja:
17.6.2002.
Posjeta: 683 *