Izvorni znanstveni članak
https://doi.org/10.20471/acc.2023.62.s1.09
Comparison of Tracheal Aspirates in the Period Before and After the Start of the COVID-19 Pandemic in the Intensive Care Unit in a Tertiary Hospital
Ivana Jakić
; Osijek University Hospital, Osijek, Croatia
Ines Tamaš
; School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Maja Bogdan
; Osijek University Hospital, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Alan Sminderovac
; Koprivnica General Hospital, Koprivnica, Croatia
Ivana Gugić Madunović
; Osijek University Hospital, Osijek, Croatia
Mislav Gugić
; Institute for Public Health of Vukovar-Srijem County, Vukovar, Croatia
Slavica Kvolik
; Osijek University Hospital, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Sažetak
Changes in working methods and diagnostics using matrix-assisted laser desorption/
ionization time-of-flight mass spectrometry (MALDI-TOF) diagnostics that occurred after the
start of the COVID-19 pandemic could show differences in the prevalence of positive microbiological
samples. In a retrospective study, a total of 442 tracheal aspirates in the pre-pandemic period (Period
A, 2018, 198 patients, age median 69 (57-78)) and 277 samples in the pandemic period (Period B,
2021, 147 patients, age 68 (56-77) (p=0.585) obtained after the start of the pandemic were analyzed.
A total of 176 patients had at least 1 positive result. In Period A, there were 245 (55%) and in Period
B 186 (68%) sterile samples (p=0.001). The most frequently isolated pathogens were Acinetobacter baumannii
in 86 patients from Period A and 32 patients from Period B, i.e., 43% vs. 21.7% of all positive
isolates (p=0.247), followed by Pseudomonas aeruginosa in 29 patients in Period A (14.6%) vs. 7 (3%)
(p=0.112) in Period B. A statistically significant increase was observed in the incidence of Enterobacterales
(16.6% vs. 32.6%, p=0.002), especially Klebsiellae spp. Although overall mortality decreased in
Period B, changes in the working methods and diagnostics did not result in changes in the mortality
of patients whose tracheal aspirates were sampled.
Ključne riječi
Spectrometry, mass; Matrix-assisted laser desorption-ionization; Pneumonia; Intensive care units; Microbiology
Hrčak ID:
307477
URI
Datum izdavanja:
1.4.2023.
Posjeta: 230 *