Izvorni znanstveni članak
Histoenzymatic and Immunocytochemical Characteristics of Extravillous Trophoblast Cells of Placental Basal Plate as Parameter of Their Function in Hypertensive Pregnancy
C. Lež
A. Pirkić
D. Buković
R. Fureš
J. Djelmiš
M. Ivanišević
B. Hodek
Sažetak
An intense activity of enzymes which actively participate in the renin-angiotensinaldosterone
system was shown in extravillous trophoblast cells which are involved in
the performing of spiral arteries into uteroplacental vessels. The hydrolase activity in
villous trophoblast underwent important variations, but it was constant in cells of the
extravillous trophoblast. Activity of lysosomal hydrolases, of leucine aminopeptidase
and N-acetyl glucosaminidase type, was markedly positive in X-cells, while negative in
the villous trophoblast. Beta glucuronidase activity has shown moderate activity in cells
of extravillous trophoblast, while in villous trophoblast it was weakly emphasized or
negative. Intense activity of prostaglandin E2 dehydrogenase in the way of strongly emphasized
microsomal reaction was noted exclusively in extravillous cells of basal plate,
especially in perivascular cell groupings. Within all examined enzymes activities, only
the membranous activity of alkaline phosphatase was of the same intensity in cells of
extravillous trophoblast. Lacking of penetration of these cells into the spiral arteries
wall in EPH-gestosis, which also means loss of their close contact with the blood of a
pregnant, implicates the practical meaning of these observations.
Ključne riječi
Hrčak ID:
28269
URI
Datum izdavanja:
17.6.2002.
Posjeta: 826 *