Sažetak sa skupa
Internal jugular vein thrombosis caused by invasive pharyngeal cancer: a case report and literature review
Filip Tudor
orcid.org/0000-0001-6386-0444
; KBC Rijeka, Klinika za otorinolaringologiju i kirurgiju glave i vrata, Rijeka, Hrvatska
Alan Pegan
; KBC Sestre milosrdnice, Klinika za otorinolaringologiju i kirurgiju glave i vrata, Zagreb, Hrvatska
Darko Solter
; KBC Sestre milosrdnice, Klinika za otorinolaringologiju i kirurgiju glave i vrata, Zagreb, Hrvatska
Sažetak
INTRODUCTION: Internal jugular vein (IJV) thrombosis is a potentially life-threating disease and can occur
at any level. Variety of factors can induce thrombosis, but it is most often found following IJV catheterization,
neck dissection, injuries, infectious disease, in ovarian hyperstimulation syndrome or in malignant neoplasms.
Unlike thyroid cancer, in which thrombosis of the jugular vein have been relatively often described, thrombosis
of the internal jugular vein in head and neck squamous cell cancer is extremely rare. OBJECTIVE: We report
a unique case of a very advanced, locally invasive pharyngeal tumor causing thrombosis of the internal jugular
vein. Literature review of the described topic was also conducted. MATERIAL AND METHODS: A crossreferenced PubMed and Scopus (EMBASE) search was performed and relevant data were extracted
accordingly. The search was performed using the following key-words and Boolean operators: “head and neck
cancer AND squamous cell cancer AND internal jugular vein thrombosis”. RESULTS: According to PubMed
and Scopus search only two similar cases were found. The first patient had supraglottic SCC with N3 lymph
node invading IJV. The second patient developed SCC of the thyroid gland with a large IJV thrombosis. Both
patients were treated bimodally, but developed recurrences and died soon after the treatment. In our case,
patient was treated with radical surgery. Radical dissection of the right side of the neck and selective dissection
of the left side of neck levels II-IV were performed. Furthermore, total laryngectomy, subtotal pharyngectomy
and total thyroidectomy en bloc were performed. Reconstruction was made with a free fasciocutaneous
anterolateral thigh flap. Despite the patient's poor general condition, IJV thrombosis, bulbus and sigmoid sinus
thrombosis, and several comorbidities, he was considered for curative therapy and is still alive, in good general
shape, 7 months after the surgery. DISCUSSION: The choice of treatment for this kind of patients is not
standardized due to its rare occurrence. Even though IJV thrombosis carries a high chance of distant metastasis
and local recurrence and consequently causing poor survival, the question arises what the best therapeutic
option is. More documented cases are undoubtedly required to draw a more solid conclusion
Ključne riječi
Head and neck cancer; Internal jugular vein; Squamous cell cancer; Thrombosis
Hrčak ID:
308127
URI
Datum izdavanja:
19.9.2023.
Posjeta: 135 *