Izvorni znanstveni članak
Hepatocyte Growth Factor Levels in Croatian Healthy and Alcoholic Liver Cirrhosis Patients
N. Antoljak
E. Topić
M. Duvnjak
N. Vrkić
I. Žuntar
Sažetak
Hepatocyte growth factor (HGF) is a most potent hepatocyte mitogen, and plays a
mayor role in liver regeneration during injury. The aim of this study was to evaluate
HGF values in Croatian healthy and alcoholic liver cirrhosis patients (AC). The HGF
and standard laboratory tests of liver damage were measured in 33 AC patients, and 41
healthy subjects. HGF was measured by using an ELISA method. The HGF levels were
higher in cirrhotic patients than in healthy subjects (median value is 0.78 vs. 0.19 ng/ml,
p < 0.001). Japanese study showed similar values of HGF for healthy subjects and AC
subjects. The HGF values in patients depend on grade of illness. There was found significant
correlation between HGF and almost all standard liver damage tests. The ROC
analysis showed that measuring of HGF had convincingly best accuracy than other parameters,
and seems to be useful in classifying grade of illness.
Ključne riječi
Hrčak ID:
28344
URI
Datum izdavanja:
18.6.2001.
Posjeta: 785 *