Acta clinica Croatica, Vol. 62. No. 2, 2023.
Prethodno priopćenje
https://doi.org/10.20471/acc.2023.62.02.17
Salivary Melatonin Values Significantly Correlate with Reduced Quality of Life in Chronic Spontaneous Urticaria Patients: a Pilot Study
Iva Bešlić
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Alen Vrtarić
; Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 3University of Applied Health Sciences, Zagreb, Croatia
Ante Bešlić
; University of Applied Health Sciences, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ivana Škrinjar
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Department of Oral Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Danijel Crnković
; Department of Psychiatry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Liborija Lugović-Mihić
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sažetak
Chronic spontaneous urticaria (CSU) is a dermatological disorder accompanied
by itching that greatly affects the quality of life and quality of sleep. Therefore, it is assumed that
CSU patients consequently experience reduced melatonin secretion and lower values of serum or
salivary melatonin. This pilot study included 20 patients with CSU (chronic urticaria of unknown
etiology that lasts for more than 6 weeks) and 10 healthy controls. All subjects were examined by
a dermatovenereologist-allergist, as well as an oral pathologist, to exclude oral pathological conditions.
Salivary melatonin levels were determined by ELISA and all subjects completed a standardized
Dermatology Life Quality Index questionnaire and Pittsburgh Sleep Quality Index on the
same day they gave a saliva sample for analysis. According to our results, 86% of CSU patients had
decreased values of salivary melatonin, and lower salivary melatonin values significantly correlated
with a reduced quality of life in CSU patients. This study was the first to analyze melatonin in CSU
patients, also suggesting a possible new therapeutic option for the treatment of CSU.
Ključne riječi
Melatonin; Salivary melatonin; Chronic spontaneous urticaria; Sleep disorder; Therapeutic options
Hrčak ID:
308844
URI
Datum izdavanja:
1.8.2023.
Posjeta: 376 *