Izvorni znanstveni članak
Effect of Insulin and Insulin-Like Growth Factor I on Fetal Macrosomia in Healthy Women
J. Jakšić
F. Mikulandra
M. Periša
T. Miletić
Ž. Dubovečak
D. Škugor
I. Tadin
Sažetak
The aim of the study was to determine the values of insulin, insulin-like growth factor
I (IGF- I) and glucose in the umbilical cord blood of macrosomic ( 4000 g) and control
(3,000–3,500 g) infants born to healthy mothers, and to assess their possible correlation
with the newborns’ birth weight and maternal anthropometric parameters. A series
of 207 macrosomic term infants, and 200 control term infants, born to healthy mothers
with normal oral glucose tolerance test throughout gestation, were studied. The glucose
concentration did not differ between the macrosomic and control group while macrosomic
infants had significantly higher values of insulin and IGF-I. Female macrosomic
infants had significantly higher levels of insulin and IGF-I than male macrosomic infants.
The levels of insulin and IGF-I, but not levels of glucose, differed between the
macrosomic and control group according to the maternal weight, height, pregestational
body mass index, weight gain during gestation, and maternal birth weight. The maternal
anthropometric parameters were significantly greater in the macrosomic infants.
Accordingly, macrosomia was concluded to be a multifactorial condition.
Ključne riječi
Hrčak ID:
28442
URI
Datum izdavanja:
17.12.2001.
Posjeta: 938 *