Recenzija, Prikaz slučaja
Current Concept on the Anticaries Fluoride Mechanism of the Action
K. Rošin-Grget
I. Linčir
Sažetak
The paper discusses a possible new concept of the role of fluoride and its mechanism
of action in caries prevention. In the past fluoride inhibition of caries was ascribed to reduced
solubility due to incorporation of fluoride (F–) into the enamel minerals (firmly
bound fluoride or fluorapatite). Based on the new findings, it appears that fluoride, either
released into or present in the fluid phase bathing the hard tissue, is more important for
the reduction of caries development and progression. There is convincing evidence that
fluoride has a major effect on demineralization and remineralization of dental hard tissue
and that it interferes with acid production from cariogenic bacteria. The provision
of dissolved fluoride is the key to successful therapy. The source of this fluoride could either
be fluorapatite or calcium fluoride (CaF2) (like) precipitates, which are formed on
the enamel and in the plaque after application of topical fluoride. The precipitates of
calcium fluoride do not dissolve quickly as was initially believed. Calcium fluoride coating
at neutral pH by pellicle proteins and phosphate is the main reason for this. The dissolution
of the fluoride from calcium fluoride is pH dependent. At lower pH, the coating
is lost and an increased dissolution rate of calcium fluoride occurs. The CaF2 , therefore,
act as an efficient source of free fluoride ions during the cariogenic challenge. These are
subsequently incorporated into the enamel as hydroxyfluorapatite or fluorapatite.
Ključne riječi
Hrčak ID:
28465
URI
Datum izdavanja:
17.12.2001.
Posjeta: 8.868 *