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Alloxan Induced Cataract in a Rat

Z. Balog
R. Klepac
S. Rošić
T. Jukić-Lešina

Puni tekst: engleski pdf 56 Kb

str. 43-46

preuzimanja: 658



We have measured lipid peroxidation and the activity of antioxidant enzymes in lenses
of alloxan injected rats. After 12 weeks alloxan treated rats developed lens cataract.
Diabetes rats had both lower lens weight and lower level of proteins in soluble fraction
of lens homogenate. Alloxan treatment is associated with a significant increase of thiobarbituric
acid reactive substances and the activity of antioxidant enzymes superoxide
dismutase and catalase. However, diabetes decreased the activity of glutathione peroxidase
in rat lenses. These results show that alloxan, which changes antioxidant status
in rat lenses, may cause complications associated with diabetes.

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