Pregledni rad
https://doi.org/10.26800/LV-145-supl4-12
The pathogenesis of cognitive decline after cardiac surgery: A Narrative Review
Sandro Glumac
orcid.org/0000-0002-9533-1261
; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinički bolnički centar Split, Split, Hrvatska
*
Goran Kardum
orcid.org/0000-0002-5766-361X
Cristijan Bulat
Mladen Carev
Nenad Karanović
* Dopisni autor.
Sažetak
Although the rates of postoperative complications following cardiac surgery are constantly declining because of improvements in medical techniques, the incidence of postoperative cognitive decline (POCD) is still unchanged and has become the most common postoperative complication. The pathogenesis of POCD is still poorly understood, and universally accepted POCD definition has not yet been established. POCD occurrence has a significant repercussion on patient health, but also on the community, given that POCD is associated with reduced work ability, early withdrawal from the workforce and significantly increased use of healthcare resources. The purpose of this narrative review is to summarize and evaluate the latest findings based on the search of available literature, with special attention paid to the pathogenesis of POCD. Therefore, we searched the Web of Science (All Databases) and Scopus databases for the best evidence about this significant postoperative complication. We revealed that the inflammatory response to cardiac surgery plays a key role in the mutually overlapping processes included in POCD development, and that the methodological inconsistency in defining POCD among researchers makes a significant obstacle in the investigation of this issue.
Ključne riječi
CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; COGNITIVE DYSFUNCTION; NEUROPSYCHOLOGICAL TESTS; POSTOPERATIVE COMPLICATIONS
Hrčak ID:
310271
URI
Datum izdavanja:
20.11.2023.
Posjeta: 724 *