Case report, case study
Giant Primary Apocrine Carcinoma of the Frontal Region: Clinical Presentation, Histopathological Features, and Surgical Treatment
Dragana Petrović Popović
; Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, Belgrade, Serbia
Marijan Novaković
; Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, Belgrade, Serbia
Milan Stojičić
; Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, Belgrade, Serbia
Dimitrije Brašanac
; Institute of Pathology, Faculty of Medicine, University of Belgrade, Serbia
Mirjana Petrović-Elbaz
; James J. Peters Department of Veterans Affairs Medical Center, New York, USA
Abstract
Primary cutaneous apocrine carcinoma (PCAC), a subtype of sweat
gland carcinoma, is an extremely rare malignant neoplasm. Distinguishing an
apocrine carcinoma from a breast carcinoma metastasis is difficult even for a
pathologist. Most arise in regions of high apocrine gland density like the axilla,
and rarely on the scalp and eyelid, but they can occur elsewhere on the skin.
Primary cutaneous apocrine carcinoma of the scalp is a rare malignancy most
often reported in the literature as case reports or small case series. The giant
form of primary cutaneous apocrine carcinoma in the frontal region has not
been described in the literature, to the best of our knowledge. There are no
established protocols for treatment of primary cutaneous apocrine carcinoma.
We report a case of a giant primary cutaneous apocrine carcinoma localized
in the frontal region. A definitive diagnosis of a primary cutaneous apocrine
carcinoma was established by biopsy with microscopic and immunohisto-
chemical analysis. Wide surgical excision and reconstruction with large local
transposition flap and split thickness skin grafts for secondary defect were our
therapy of choice. Primary cutaneous apocrine carcinoma is a very rare ma-
lignancy, and the giant form has not yet been described. Surgical treatment
provided the patient with tumor-free status as well as satisfactory aesthetical
appearance and quality of life.
Keywords
primary cutaneous apocrine carcinoma; diagnosis; surgical treatment; reconstruction
Hrčak ID:
311540
URI
Publication date:
16.3.2023.
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