Izvorni znanstveni članak
Insulin Growth Factor-1 Status in Hidradenitis Suppurativa: A French Institutional Pilot Study
Perrine Rousseau
; Nantes University, CHU Nantes, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302/EMR6001, Nantes, France
Alexandra Poinas
; Nantes University, CHU Nantes, INSERM, CIC1413, Nantes, France
Damien Masson
; Nantes University, CHU Nantes Clinical Bio- chemistry Laboratory and INSERM U1235 TENS, Nantes, France
Kalyane Bach-Ngohou
; Nantes University, CHU Nantes Clinical Bio- chemistry Laboratory and INSERM U1235 TENS, Nantes, France
Jean-Michel Nguyen
; Nantes University, CHU Nantes Epidemiology and Biostatistics Department, CRCINA, INSERM1232, University Nantes, Nantes, France
Marie Le Moigne
; Nantes University, CHU Nantes, INSERM, CIC1413, Nantes, France
Barbara Bregeon
; Nantes University, CHU Nantes, INSERM, CIC1413, Nantes, France
Florence Vrignaud
; Nantes University, CHU Nantes, INSERM, CIC1413, Nantes, France
Amir Khammari
; Nantes University, CHU Nantes, INSERM, CIC1413, Nantes, France
Brigitte Dréno
; Nantes University, CHU Nantes, INSERM, CIC1413, Nantes, France
Sažetak
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease
of the follicles in the apocrine glands and is associated with a deficiency in the
innate immunity of the skin. It is characterized by the occurrence of nodules, ab-
scesses, fistulas, scars.
Objective: Although a relationship has already been demonstrated between HS
and innate immunity, IGF-1 status in patients with HS is still unknown. The objec-
tive of this pilot study was to determine IGF-1 status in patients with HS as well as
its potential relationship with the clinical profile of the disease.
Methods: This monocentric and cross-sectional study involved 39 patients hospi-
talized at the Dermatology Department of CHU Nantes between November 2014
and January 2018. Clinical data and IGF1 status were collected during the follow-
up consultation.
Results: Forty-nine percent of the patients had very low levels of IGF-1. At the
clinical level, these patients were young and with a short duration of disease. The
major difference was that IGF1-deficient patients had a higher BMI than others.
The others factors differing between the two patient groups did not reach statisti-
cal significance.
Conclusion: This exploratory pilot study indicates that HS with a low level of
IGF-1 could represent a specific phenotype of patients with HS. These pre-
liminary results have to be confirmed with a larger cohort, as they could
have practical consequences in the therapeutic care of these patients.
Ključne riječi
hidradenitis suppurativa; patient phenotype; insulin growth fac- tor-1
Hrčak ID:
311551
URI
Datum izdavanja:
15.6.2023.
Posjeta: 202 *