Stručni rad
Alterations in Inflammation Markers Due to Disease Activation in Autoimmune Bullous Diseases
Gokhan Sahin
orcid.org/0000-0002-7129-4339
; Ondokuz Mayis University Medical Faculty, Department of Dermatology, Samsun, Turkey
Esra Pancar Yuksel
; Ondokuz Mayis University Medical Faculty, Department of Dermatology, Samsun, Turkey
Fatma Aydin
; Ondokuz Mayis University Medical Faculty, Department of Dermatology, Samsun, Turkey
Sažetak
Background: In the pathogenesis of autoimmune bullous diseases, there is
an underlying autoinflammation against epidermal/subepidermal structures
caused by many inflammatory cells.
Aim / Objectives: In this study, we aimed to determine the alterations in in-
flammatory markers regarding disease activity in autoimmune bullous diseas-
es and to discuss their contribution to the pathogenesis.
Methods: A total of 191 patients with pemphigus vulgaris (PV) and 46 pa-
tients with bullous pemphigoid (BP) who were admitted to the outpatient
clinic at the Department of Dermatology were included. The mean platelet
volume (MPV) values, thrombocyte, eosinophil, and basophil counts, eryth-
rocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels prior and
following treatment were examined retrospectively from the patients’ medical
files. A decrease of 75% or more in Autoimmune Bullous Skin Disorder Inten-
sity Score (ABSIS) was considered a remission period.
Results: Among patients with PV, 78 (40.8%) were men and 113 (59.2%) were
women. In patients with PV, MPV value, eosinophil, basophil count, and ESR
and CRP levels showed a statistically significant decrease during the remission
period, whereas alteration in platelet count was not statistically significant.
Eighteen (39.1%) of patients with BP were men and 28 (60.9%) were women. In
patients with BP, MPV value, eosinophil count, and ESR and CRP levels showed
a statistically significant decrease during the remission period. However, plate-
let and basophil counts revealed no statistically significant alterations.
Limitations: Evaluation of the ABSIS scores of the followed-up patients by dif-
ferent observers due to the long time interval can be considered among the
limitations of the study.
Conclusion: Eosinophils, basophils, and thrombocytes to the inflammation in
the pathogenesis of PV, whereas eosinophils and thrombocytes may contrib-
ute in the pathogenesis of BP. During the activation period of autoimmune
bullous diseases, the level of acute-phase reactants is higher than in the remis-
sion period.
Ključne riječi
autoimmune bullous diseases; basophil; eosinophil; ESR; MPV
Hrčak ID:
311638
URI
Datum izdavanja:
15.6.2023.
Posjeta: 167 *