Izvorni znanstveni članak
https://doi.org/10.21857/94kl4clz3m
Tapping the potential of bone regeneration by delivery of concentrated extracellular vesicles to the fracture site: A new horizon in bone regeneration therapy research?
Lovorka Grgurević
; Zavod za anatomiju "Drago Perović", Medicinski fakultet Sveučilišta u Zagrebu
Rudjer Novak
; Centar za translacijska i klinička istraživanja, Zavod za proteomiku, Medicinski fakultet Sveučilišta u Zagrebu
Stela Hrkač
; Zavod za kliničku imunologiju, alergologiju i reumatologiju, Klinička bolnica Dubrava
Grgur Salai
; Zavod za pulmologiju, Klinička bolnica Dubrava
Jadranka Bubić
; BIMIS - Biomedicinsko istraživačko središte Šalata, Medicinski fakultet Sveučilišta u Zagrebu
Dinko Mitrečić
; BIMIS - Biomedicinsko istraživačko središte Šalata, Medicinski fakultet Sveučilišta u Zagrebu
Marija Lipar
; Zavod za ortopediju i oftalmologiju, Veterinarski fakultet Sveučilišta u Zagrebu
Tomislav Vlahović
; Klinika za traumatologiju, Klinički bolnički centar "Sestre Milosrdnice"
Sažetak
Background A small pilot study was conducted in order to investigate in situ regenerative potential of extracellular vesicles (EVs) in a rat subcutaneous implant model.
Material and methods An implant device was implanted in the axillary regions of four animals and consisted of a rat ABC enriched with an EV isolate obtained from human patients 7-21 days post bone fracture, or healthy individuals.
Results Upon histological examination of the implanted devices, there were clear evidence of early signs of immature cartilage and bone formation in the implants of fracture-EV treated animals, 21 days post implantation.
Conclusion These preliminary results suggest a potential for near-term innovation in the development of an affordable, non-invasive and completely autologous therapeutic device that can potentially
enhance the existing regenerative capacity of skeletal tissues. EV can be used to concentrate the body’s inherent regenerative potential and utilise it as a personalised self-healing therapy.
Ključne riječi
extracellular vesicles; regeneration; subcutaneous assay; bone; fracture
Hrčak ID:
312649
URI
Datum izdavanja:
22.12.2023.
Posjeta: 124 *