Veterinarski arhiv, Vol. 93 No. 6, 2023.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.2279
Veterinary compounding: the impact of different gelling agents on the rheological characteristics and release kinetics from meloxicam oral gels in the treatment of cats
Zorana Kovačević
; Department of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Novi Sad, Serbia
Snežana Mugoša
; Faculty of Medicine, University of Montenegro, Podgorica, Montenegro; Institute for medicine and medical devices of Montenegro, Montenegro
Mladena Lalić-Popović
; Department of Pharmacy, Faculty of Medicine, Univerity of Novi Sad, Novi Sad, Serbia; Centre for Medical and Pharmaceutical Investigations and Quality Control (CEMPhIC), Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Slobodan Stojanović
; Department of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Novi Sad, Serbia
Nadežda Tešin
; Department of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Novi Sad, Serbia
Dragoljub Marić
; Department of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Novi Sad, Serbia
Nemanja Todorović
; Department of Pharmacy, Faculty of Medicine, Univerity of Novi Sad, Novi Sad, Serbia
Frane Božić
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Worldwide, the growing number of pets has increased the use of veterinary drugs, as well as individualised therapy such as compounded drugs. If a suitable formulation or drug is not registered for veterinary species, drugs are compounded. This also includes pharmaceutical forms which are easy to administer, such as semi-solid preparations (gels and pastes) for oral use in order to enhance drug administration and adherence. The number of non-steroidal drugs (NSAIDs) approved for use in cats is relatively small. NSAIDs represent the largest group of drugs with adverse drug experience, but meloxicam has advantages in relation to all of them because of its safety for use in cats. In this study, the pharmaceutical-technological characterisation of oral gels for cats made with different gelling agents (carbomer, xanthan gum, carmellose sodium and hypromellose) was undertaken. Subsequently, four different samples were prepared and designed for veterinary use (using meloxicam, gelling agents and taste enhancer), and then the pH value, rheological characterisation and drug release were determined. The results demonstrated that addition of the taste enhancer influenced the rheological properties of the tested oral gels. It was found that the rate of meloxicam release was the highest from the oral gel prepared with carbomer (Carbopol® 974P), where complete meloxicam dissolution was observed after 5 minutes. On the basis of these results, it was concluded that Carbopol 974P has a certain advantage over the other gelling agents used in this study. Further work is required to assess the palatability of the oral gel for cats in clinical settings.
Ključne riječi
oral gel; cats; meloxicam; veterinary compounding
Hrčak ID:
314178
URI
Datum izdavanja:
15.1.2024.
Posjeta: 122 *