Acta clinica Croatica, Vol. 62. No. 3, 2023.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2023.62.03.8
Does the Presence of Chronic Lymphocytic Thyroiditis Affect Diagnostic Value of Fine Needle Aspiration Biopsy in Bethesda Category III Nodules?
Şevki Pedük
orcid.org/0000-0002-7476-384X
; Mardin Training and Research Hospital, Artuklu/Mardin, Turkey
Belma Koçer
; Sakarya University, Training and Research Hospital, Sakarya, Turkey
Sažetak
This study aimed to determine the relationship between the presence of Hashimoto’s
thyroiditis (HT) and malignancy rates with prognostic factors in thyroid nodules diagnosed as
Bethesda category III, and to examine the effect of HT on diagnostic value of fine-needle aspiration
biopsy (FNAB). Demographic information, preoperative examination, and final pathological
evaluation of patients with Bethesda category III (AUS-FLUS) nodules who had been operated
on in our department over the last 6 years were analyzed. Statistical analyses were performed using
the Student’s t-test, Mann-Whitney U test and χ2-test and logistic regression analysis using SPSS
version 22 software. The malignancy rate on final pathology of 159 patients was 24.5%. Malignancy
rates were found to be higher in patients with HT coexistence (30.7% vs. 21.5%, p=0.20). Poor
prognostic factors such as multifocality, number of metastatic lymph nodes (p=0.04), and extrathyroidal
extension were more common in patients with cancer in the pathology specimen who were
in the non-HT group. It cannot be said that HT decreases diagnostic value of FNAB in lesions
diagnosed with AUS-FLUS. The lower incidence of poor prognostic factors in the HT group may
be attributed to cytotoxic cell dominance in tumor immunity.
Ključne riječi
Carcinogenesis; Endocrine surgery; Immunology; Pathomorphological diagnosis of tumors; Prognostic factors
Hrčak ID:
315073
URI
Datum izdavanja:
1.11.2023.
Posjeta: 86 *