Review article

Immunosuppressive Therapy After Kidney Transplantation

Nikolina Bašić-Jukić
Marina Kljajić

Abstract

Kidney transplantation is the method of choice for treatment of end-stage kidney failure. Kidney transplant recipients need to use immunosuppressive therapy to avoid rejection. Choice of immunosuppressive drugs depends on the time since transplantation, etiology of the primary kidney disease, and immunological matching, and should be highly personalized. Biological agents are used for induction, while maintenance treatment is mostly based on triple-drug therapy containing calcineurin inhibitors, corticosteroids, and antiproliferative drugs. Besides the desired immunosuppressive effects, immunosuppressives are linked to a wide spectrum of different side-effects. For this reason, immunosuppressive protocols should be individualized based on the risk factors which are unique for each patient. The current review aims to describe the major characteristics of most frequently used immunosuppressive drugs, their mechanism of action, and side-effects.

Keywords

immunosuppressive drugs; kidney transplantation; tacrolimus; cyclosporine; mycophenolate; everolimus, sirolimus

Hrčak ID:

315855

URI

https://hrcak.srce.hr/315855

Publication date:

9.4.2024.

Article data in other languages: croatian

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