Stručni rad

https://doi.org/10.37797/ig.42.2.2

Prevalence of Human Papillomavirus in Laryngeal, Oropharyngeal and Oral Cavity Carcinomas in Zadar County, Croatia

Ivica Nekić orcid.org/0000-0002-0921-1571 ; Department of Otorhinolaryngology, Zadar General Hospital, 23000 Zadar, Croatia
Alan Medić orcid.org/0000-0003-2637-8418 ; Department of Epidemiology, Zadar Institute of Public Health, 23000 Zadar, Croatia; Department of Health Studies, University of Zadar, 23000 Zadar, Croatia
Dinko Puntarić ; Croatian Catholic University, 10000 Zagreb, Croatia
Tatjana Nemeth Blažić ; Croatian Institute of Public Health, Division for Epidemiology of Communicable Diseases, Reference Centre of the Epidemiology of the Ministry of Health, 10000 Zagreb, Croatia
Nataša Lisica Šikić orcid.org/0000-0003-3371-1151 ; Department of Pathology, Cytology, and Forensic Medicine, Zadar General Hospital, 23000 Zadar
Suzana Konjevoda ; Department of Health Studies, University of Zadar, 23000 Zadar, Croatia; Department of Ophthalmology, Zadar General Hospital, 23000 Zadar, Croatia
Diana Nonković orcid.org/0000-0003-0879-3554 ; Department of Epidemiology, Teaching Institute of Public Health, Split and Dalmatia County, 21000 Split, Croatia
Jadranka Sambunjak ; Department of Laboratory Medicine, Zadar General Hospital, 23000 Zadar, Croatia
Boris Dželalija ; Department of Health Studies, University of Zadar, 23000 Zadar, Croatia

Sažetak

We present a retrospective research of HPV testing of tissue samples, by the polymerase chain reaction method (PCR), in patients that underwent surgery due to squamous cell carcinoma of the oral cavity, oropharynx or larynx in Zadar General Hospital in the period from 2007 to 2016.
Out of 99 patients included in this study, 89 (89,9%) were men with median age of 62.3 years and ten (10,1 %) were women with median age of 66 years. According to the cancer site, the percentage of HPV positive carcinoma tissue samples of larynx carcinoma, oral cavity carcinoma and oropharyngeal carcinoma were 25.8%, 26.9% and 18,2 %, respectively. According to the HPV genotype, among all cancer sites, in 60% (n=15) HPV 16 were detected, and in 40% mixed HPV infection, that is, in 32% (n=8) HPV 16, 26, 34, 53 and in 8% (n=2) HPV 16, 18, 26, 34, 53.
The presented research results support the need for stronger public health promotion of vaccines against HPV, and the selection of the best strategy for the implementation of vaccination to prevent cancer of the larynx, oropharynx and oral cavity among men.

Ključne riječi

cancer; larynx; oropharynx; oral cavity; HPV; epidemiology; Zadar; Croatia

Hrčak ID:

316043

URI

https://hrcak.srce.hr/316043

Datum izdavanja:

15.4.2024.

Podaci na drugim jezicima: hrvatski

Posjeta: 73 *