Original scientific paper
Atorvastatin-induced Lupus Erythematosus Tumidus: A Case Report and Literature Review
Katarina Trčko
; Department of Dermatology and Venereal Diseases, University Medical Centre Maribor, Maribor, Slovenia
Nuša Lukinovič
; Faculty of Medicine, University of Maribor, Maribor, Slovenia
Boštjan Luzar
orcid.org/0000-0002-7291-8174
; Institute of Pathology, Medical Faculty Ljubljana, University of Ljubljana, Ljubljana, Slovenia
Abstract
Lupus erythematosus tumidus (LET) is a rare photosensitive skin disease classified as a separate subtype of cutaneous lupus erythematosus. Clinically, it is characterized by erythematous plaques on sun-exposed areas. Typical
histopathological findings are perivascular and periadnexal lymphohistiocytic
infiltrates and prominent mucin deposition in the dermis. Treatment is based
on photoprotection, topical corticosteroids, and antimalarial drugs. The exact
pathogenesis of the disease is unknown. Drugs are considered a minor risk factor for the development of LET. We present a case of a 56-year-old woman who
developed LET after starting treatment with atorvastatin. We describe her clinical course and review the literature concerning the cutaneous adverse reactions
induced by statin drugs. To our knowledge, this is the first case of statin-induced
LET. We conclude that statins can induce LET and that it is important for clinicians
to be aware of this potential adverse effect associated with statins.
Keywords
statin; cutaneous lupus erythematosus; intermittent cutaneous lupus; lupus erythematosus tumidu
Hrčak ID:
316430
URI
Publication date:
15.9.2023.
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